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KMID : 1145120180160010001
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Asian Journal of Beauty and Cosmetology
2018 Volume.16 No. 1 p.1 ~ p.9
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New Development of Natural Depigmentation Agent from Anemarrhena asphodeloides Root Extracts by Inhibition of Melanin Biosynthesis
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Seo Soo-Kyung
Han Seong-Jeong
Ku Chang-Sub
Kim Dae-Hyun
Ryu Ja-Hyun
Baek Ji-Hwoon
Koh Jae-Sook
Jang Dong-Il
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Abstract
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Purpose: This study aimed to confirm the depigmentation effects from Anemarrhena asphodeloides root extracts (AARE).
Methods: We assessed tyrosinase inhibition activity of AARE and investigated the biosynthesis of melanin in B16F10 melanoma cells and subjected to clinical trials with AARE creams.
Results: Tyrosinase activity and melanin biosynthesis induced by α-melanocyte stimulating hormone (α-MSH) were inhibited by AARE in a concentration-dependent manner. In particular, at 25 μg/mL concentration, melanin biosynthesis was more effectively inhibited by AARE (28.4%) than arbutin (24.7%; a well-known melanin synthesis inhibitor). In clinical trials, we investigated the changes in human skin brightness values over eight weeks using a cream formulation that contained 2% AARE after inducing pigmentation via ultraviolet irradiation. We showed that the hyperpigmentation degree, melanin index, and skin brightness were significantly improved.
Conclusion: AARE is expected to become widely available as a functional cosmetic material for skin whitening.
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KEYWORD
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Anemarrhena asphodeloides, Tyrosinase, Natural depigmentation agent, Skin brightness, Melanin
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